Wirth R, Volf V
Health Phys. 1985 Nov;49(5):865-71. doi: 10.1097/00004032-198511000-00018.
The effect of Np mass and the acidity of the administered Np solutions as well as the age, sex and nutritional status of the animals injected or gavaged with 239Np or 237Np were determined. The latter factor proved to be dominant for absorption of Np from the gut. Thus in fasting weanling and young adult male rats, the absorption of 239Np was sixfold higher (0.18% and 0.12%, respectively) than in fed ones (0.03% and 0.02%, respectively). Absorption by fasted adult females was 0.05% of the administered 239Np, about half of that of adult males. Raising the Np-mass gavaged to fasted female rats to 1 and 10 mg 237Np/kg resulted in an absorption of 0.23% and 0.26%, respectively. Thus, an increased absorption of Np in adult rats seems to be expected only if a large mass is ingested. No dependence of the absorption of Np on nitric acid concentration was found. The data obtained after oral administration of 238Pu and 239Np to adult rats suggest that the f1 factor recommended by the ICRP for fractional absorption of soluble Np compounds from the gut should be decreased, whereas the f1 factor for soluble Pu compounds should be raised.
测定了钚质量、所给予的钚溶液的酸度以及用239Np或237Np注射或灌胃的动物的年龄、性别和营养状况的影响。结果证明，后一个因素对肠道中钚的吸收起主导作用。因此，在禁食的断奶幼鼠和成年雄性大鼠中，239Np的吸收分别比进食的大鼠高6倍（分别为0.18%和0.12%）（分别为0.03%和0.02%）。禁食成年雌性大鼠的吸收量为所给予的239Np的0.05%，约为成年雄性大鼠的一半。将灌胃给禁食雌性大鼠的钚质量提高到1和10 mg 237Np/kg，吸收量分别为0.23%和0.26%。因此，成年大鼠中钚吸收的增加似乎只有在摄入大量钚时才会出现。未发现钚的吸收与硝酸浓度有关。对成年大鼠口服238Pu和239Np后获得的数据表明，国际放射防护委员会（ICRP）推荐的用于可溶性钚化合物从肠道中分数吸收的f1因子应降低，而可溶性钚化合物的f1因子应提高。
