Karam J, Pouard P, Fiemeyer A, Mauriat P, Dubuit C
Cah Anesthesiol. 1984 Oct;32(6):473-80.
Sodium nitroprusside (SNP) is a vasodilator widely used in heart surgery. Its effects before and after bypass at normal temperature have been reported. This prospective study compares 15 patients who received SNP with 5 controls. SNP's efficacy on the systemic arterial resistance index is demonstrated during cooling and rewarming. Vasoconstriction at the end of persistent hypothermia does not respond to SNP. No signs of toxicity, neither biological (metabolic acidosis) nor clinical (respiratory or cardiac problems) were observed. SNP lowers pulmonary artery resistance index during normothermia and pulsed cardiac output, but a rebound appears 45 minutes after SNP withdrawal. SNP is usefull for anaesthesia in heart surgery with hypothermia.
硝普钠（SNP）是一种广泛应用于心脏手术的血管扩张剂。其在常温下体外循环前后的作用已有报道。这项前瞻性研究将15例接受SNP治疗的患者与5例对照患者进行了比较。研究表明，在降温及复温过程中SNP对体循环动脉阻力指数有效。持续性低温末期的血管收缩对SNP无反应。未观察到毒性迹象，无论是生物学方面（代谢性酸中毒）还是临床方面（呼吸或心脏问题）。SNP在常温及搏动心输出量时可降低肺动脉阻力指数，但在停用SNP 45分钟后会出现反弹。SNP对低温心脏手术的麻醉有用。
