Ostrand-Rosenberg S, Clements V, Cole G, DeCloux A, Marr L, Schwartzman M
Cell Differ. 1984 Dec;15(2-4):221-7. doi: 10.1016/0045-6039(84)90078-2.
Teratocarcinoma 402AX cells are induced to express major histocompatibility complex (MHC) antigens when passaged in vivo in genetically resistant host mice. Studies reported here demonstrate that MHC antigen induction is regulated in vivo in part by the synergistic action of Lyt 1 and Lyt 2 positive splenic T cells and in vitro by serum from tumor-primed resistant mice. Northern blots suggest that some teratocarcinoma 402AX MHC class I antigens may be post-transcriptionally regulated.
当畸胎癌402AX细胞在基因抗性宿主小鼠体内传代时，会被诱导表达主要组织相容性复合体（MHC）抗原。本文报道的研究表明，MHC抗原的诱导在体内部分受Lyt 1和Lyt 2阳性脾T细胞的协同作用调节，在体外受来自肿瘤致敏抗性小鼠的血清调节。Northern印迹分析表明，一些畸胎癌402AX MHC I类抗原可能受到转录后调控。
