产肠毒素大肠杆菌腹泻：流行地区的获得性免疫与传播
Enterotoxigenic Escherichia coli diarrhoea: acquired immunity and transmission in an endemic area.
作者信息
Black R E, Merson M H, Rowe B, Taylor P R, Abdul Alim A R, Gross R J, Sack D A
出版信息
Bull World Health Organ. 1981;59(2):263-8.
Abstract
Enterotoxigenic Escherichia coli (ETEC) are an important cause of diarrhoea in developing countries. Studies were made, in an endemic area of Bangladesh, of household contacts of patients with diarrhoea associated with E. coli producing heat-stable and heatlabile toxins (ST/LT) or heat-stable toxin (ST) only. It was found that 11% of contacts were infected in the 10-day study period, and that both the rate of infection and the proportion of infected persons with diarrhoea decreased with increasing age, suggesting the development of immunity. ETEC of the same serotype as that of the index patient were found in 9% of water sources used by index households, in a small number of food and drinking water specimens from the index homes, and in faeces from 3 healthy calves. The rate of infection of household members was highest in houses where there was contaminated food or water, which suggests that infection may take place in the home when contaminated water is brought in.
摘要
产肠毒素大肠杆菌（ETEC）是发展中国家腹泻的一个重要病因。在孟加拉国的一个流行地区，对腹泻患者的家庭接触者进行了研究，这些患者的腹泻与产生热稳定和热不稳定毒素（ST/LT）或仅产生热稳定毒素（ST）的大肠杆菌有关。研究发现，在为期10天的研究期间，11%的接触者受到感染，而且感染率和腹泻感染者的比例均随着年龄的增长而下降，这表明免疫力在增强。在首例患者家庭使用的9%的水源中、来自首例患者家庭的少量食品和饮用水样本中以及3头健康小牛的粪便中，发现了与首例患者血清型相同的ETEC。在有受污染食品或水的家庭中，家庭成员的感染率最高，这表明当引入受污染的水时，可能会在家庭中发生感染。
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