Marsh W L, Stevenson D R, Long H J
Cancer. 1983 Mar 15;51(6):1125-31. doi: 10.1002/1097-0142(19830315)51:6<1125::aid-cncr2820510625>3.0.co;2-u.
Although secondary leptomeningeal lymphoma is relatively common, primary leptomeningeal lymphoma is rare. We report a patient with the extremely unusual clinical and pathologic presentation of a primary T-cell lymphoma of the leptomeninges. Diagnosis was established by morphologic and immunologic studies of cerebrospinal fluid (CSF) and brain biopsy. The leptomeningeal lymphoma responded well to intrathecal chemotherapy and irradiation but the patient has severe residual motor paralysis. The clinical and pathological features of primary and secondary central nervous system (CNS) lymphoma are reviewed in reference to this most unusual patient.
虽然继发性柔脑膜淋巴瘤相对常见，但原发性柔脑膜淋巴瘤却很罕见。我们报告了一例患有原发性柔脑膜T细胞淋巴瘤，临床表现和病理表现极为罕见的患者。通过对脑脊液（CSF）和脑活检进行形态学和免疫学研究得以确诊。柔脑膜淋巴瘤对鞘内化疗和放疗反应良好，但患者仍有严重的残余运动麻痹。结合这一极为特殊的病例，对原发性和继发性中枢神经系统（CNS）淋巴瘤的临床和病理特征进行了综述。
