The 1-nitropyrene reductase of Salmonella typhimurium.
作者信息
Lu C, McCalla D R, McCarry B E
出版信息
Chem Biol Interact. 1983 Jan;43(1):67-71. doi: 10.1016/0009-2797(83)90104-7.
PMID:6336992
Abstract
We have devised a sensitive fluorimetric assay to monitor the conversion of 1-nitropyrene to 1-aminopyrene. Application of this assay to extracts of Salmonella typhimurium strains TA98 and TA100 (which are sensitive to the mutagenic and lethal effects of 1-nitropyrene) has shown that these bacteria contain 'nitropyrene reductase' activity at the low level of 10(-11) mol/min/mg protein. NADPH and NADH serve equally well as reducing agents. The nitropyrene reductase activity of strain TA100 F50 (a mutant resistant to 1-nitropyrene) was found to be considerably lower.
摘要
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