Kokubu T, Hashimoto H, Hiwada K
Chest. 1983 Feb;83(2 Suppl):359-60. doi: 10.1378/chest.83.2_supplement.359.
Oral administration of clonidine lowered the high blood pressure in two-kidney, one-clip hypertensive rats in chronic stage (three to four months), but not in one-kidney, one-clip hypertensive rats. This reduction of blood pressure was well correlated with decrease in plasma renin concentration, but not with decrease in urinary noradrenaline excretion. These results suggest that the reduction of blood pressure in two-kidney, one-clip hypertensive rats may be due to reduced renin release through the action of clonidine, while in one-kidney, one-clip hypertensive rats the sympathetic nervous activity may play little or no role in the maintenance of high blood pressure.
口服可乐定可降低两肾一夹高血压大鼠慢性期（三至四个月）的高血压，但对一肾一夹高血压大鼠无效。血压的降低与血浆肾素浓度的降低密切相关，但与尿去甲肾上腺素排泄量的降低无关。这些结果表明，两肾一夹高血压大鼠血压的降低可能是由于可乐定的作用使肾素释放减少所致，而在一肾一夹高血压大鼠中，交感神经活动在维持高血压方面可能作用很小或不起作用。
