Yomaida I, Murao M, Togashi H, Shimamura K, Koike Y, Monma Y, Saito H A
Neurosci Lett. 1979 Dec;15(2-3):249-51. doi: 10.1016/0304-3940(79)96121-4.
Daily administration of clonidine for 5 weeks (approx. 300 micrograms/kg/day, p.o.) produced significant decreases in blood pressure and renal sympathetic efferent activity in spontaneously hypertensive rats (SHR). After cessation of clonidine administration, blood pressure and sympathetic nerve activity recovered rapidly from the depressed levels to the untreated control levels. These findings could indicate that clonidine-induced hypotension and its rapid recovery to control after withdrawal of clonidine are caused by corresponding changes in sympathetic efferent nerve activity.
对自发性高血压大鼠（SHR）每日口服可乐定5周（约300微克/千克/天）可使血压和肾交感传出神经活动显著降低。停用可乐定后，血压和交感神经活动迅速从降低水平恢复到未治疗的对照水平。这些发现可能表明，可乐定引起的低血压及其停药后迅速恢复到对照水平是由交感传出神经活动的相应变化所致。
