Morgan T
Chest. 1983 Feb;83(2 Suppl):383-6. doi: 10.1378/chest.83.2_supplement.383.
Clonidine was given to patients with essential hypertension, renovascular hypertension, and hypertension with parenchymal renal disease. The drug was effective in all groups but was more effective in patients with high plasma renin concentration. Renal function did not deteriorate when the drug was used, and there was an increase in renal blood flow and a small increase in glomerular filtration rate in those with renovascular or essential hypertension. These changes may have been due to falls in plasma renin. Clonidine can be used in patients with renal disease and does not cause worsening of renal function.
可乐定被给予原发性高血压、肾血管性高血压和伴有实质性肾病的高血压患者。该药物在所有组中均有效，但在血浆肾素浓度高的患者中更有效。使用该药物时肾功能并未恶化，在肾血管性或原发性高血压患者中肾血流量增加，肾小球滤过率略有增加。这些变化可能是由于血浆肾素水平下降所致。可乐定可用于肾病患者，且不会导致肾功能恶化。
