Tanaka K, Shimada M, Sasahara A, Oya N, Fujiyama Y, Hosoda S
Exp Neurol. 1983 Jan;79(1):141-51. doi: 10.1016/0014-4886(83)90385-0.
The hypothalamic lesion induced by monosodium glutamate injection during the suckling period affected the absorption of fat from the intestine. Mice in group 1, in which the hypothalamic lesion included not only the arcuate nucleus, but also the basal preoptic area and two-thirds of the ventromedial nucleus, showed more efficient rates of fat absorption with high serum concentrations of immunoreactive insulin than the control. Mice in group 2, in which the hypothalamic lesion was confined mostly to the arcuate nucleus, also showed a significant increase in fat absorption, but elevated immunoreactive insulin was not found in the serum of these mice.
哺乳期注射谷氨酸钠所致的下丘脑损伤影响了肠道脂肪吸收。第1组小鼠的下丘脑损伤不仅包括弓状核，还包括视前区基底和三分之二的腹内侧核，与对照组相比，该组小鼠脂肪吸收效率更高，血清中免疫反应性胰岛素浓度也更高。第2组小鼠的下丘脑损伤主要局限于弓状核，其脂肪吸收也显著增加，但这些小鼠的血清中未发现免疫反应性胰岛素升高。
