[Disorder in the circladian rhythms of calcium, magnesium and phosphorus excretion in hypertension (use of the "cosinor" method)].

The daily rhythms of calcium, magnesium, and phosphorus excretion were studied in 10 healthy individuals and in 43 patients with hypertensive disease. All the subjects under study followed the standard regimen of wakefulness, sleep, and meals. The transverse "cosinor" method of rhythm study was used. Statistically significant daily rhythms of calcium, magnesium, and phosphorus excretion were revealed in healthy individuals, in which case the phenomena of internal synchronization were encountered. Daily rhythms of phosphorus and calcium excretion were revealed in patients with stage IB hypertensive disease, while the rhythm of magnesium excretion was statistically insignificant. In stage IIA the rhythms of calcium, magnesium, and phosphorus excretion are demonstrated, but desyncronization as compared to the findings in healthy individuals is observed. There are no statistically significant daily rhythms of calcium, magnesium, and phosphorus excretion in patients with stages IIB and III hypertensive disease. The change in the rhythm of magnesium excretion in patients suffering from IB stage hypertensive disease points to the early inclusion of the disturbance of its homeostasis in the development of this disease. The control mechanisms of the daily rhythms of calcium, magnesium, and phosphorus excretion are not clear to date. The study of the daily rhythms of these elements is nevertheless of definite importance in revealing disturbances in their homeostasis.