Circadian rhythms of electrolyte excretion in hypertensive patients and healthy subjects.

Analysis of data of 10 practically healthy subjects and 43 patients with hypertensive disease has indicated that there are circadian rhythms of urine volume and excretion of calcium, potassium, sodium, magnesium and phosphorus in healthy subjects. In the earlier stages of hypertensive disease significant rhythms of sodium and magnesium excretion are not revealed. However, in patients in the IIA stage of hypertension, circadian rhythms of sodium and magnesium excretion are significant. Such a phenomenon shows that the regulation of sodium and magnesium rhythmostasis has been reestablished. But in the later stages of hypertensive disease breakdown of compensatory mechanisms and dysrhythmostasis are again observed, which are expressed by absence of significant rhythms of cations and urine excretion in patients in the IIB and IIIA stages of hypertensive disease.