Theiss W, Wirtzfeld A, Fink U, Maubach P
Angiology. 1983 Jan;34(1):61-9. doi: 10.1177/000331978303400108.
Since it is still a wide-held belief that fibrinolytic therapy can clear thrombi from deep veins only while they are fresh, we retrospectively analyzed the phlebographic results obtained in 85 patients with thrombosis of the iliac and/or femoral veins with symptoms present for 1 day to 8 weeks prior to treatment. Streptokinase, urokinase, or both drugs successively were administered in these patients for a mean of 9 days (range: 2 to 26 days). Complete or partial resolution of the thrombotic occlusion was obtained in 94%, 82%, and 69%, respectively, in those patients who presented within 3 days, 1 to 2 weeks, and 3 to 4 weeks after the first appearance of symptoms. With a delay of 5 to 8 weeks the results were uniformly poor with only 1 partial recanalization in 7 patients.
由于人们普遍认为纤溶疗法只能在血栓尚新鲜时清除深静脉血栓，我们回顾性分析了85例髂静脉和/或股静脉血栓形成患者的静脉造影结果，这些患者在治疗前1天至8周出现症状。在这些患者中先后使用链激酶、尿激酶或两种药物，平均用药9天（范围：2至26天）。在症状首次出现后3天内、1至2周以及3至4周就诊的患者中，血栓闭塞完全或部分溶解的比例分别为94%、82%和69%。延迟5至8周就诊时，结果均很差，7例患者中仅有1例部分再通。
