Mehta J, Mehta P, Ostrowski N
Prostaglandins Leukot Med. 1983 Sep;12(1):49-52. doi: 10.1016/0262-1746(83)90066-5.
Human umbilical veins have been shown to produce small amounts of TXA2 in addition to PGI2. We measured relative TXA2 and PGI2 production by umbilical veins in the presence of selective TXA2 synthetase inhibitor OKY 1581. OKY 1581 treatment resulted in inhibition of TXA2 but a marked increase in PGI2 release, which may relate to diversion of cyclic endoperoxides to PGI2 pathway or to removal of a feedback control at the level of AA mobilization.
已证实人脐静脉除了产生前列环素（PGI2）外，还能产生少量血栓素A2（TXA2）。我们在选择性TXA2合成酶抑制剂OKY 1581存在的情况下，测量了脐静脉产生TXA2和PGI2的相对量。OKY 1581处理导致TXA2生成受到抑制，但PGI2释放显著增加，这可能与环内过氧化物转向PGI2途径或在花生四烯酸（AA）动员水平上消除反馈控制有关。
