层粘连蛋白、IV型和V型胶原蛋白在基底细胞癌中的免疫组织化学定位

Immunohistochemical localization of laminin, type IV and type V collagen in basal cell carcinoma.

作者信息

Van Cauwenberge D, Pierard G E, Foidart J M, Lapiere C M

出版信息

Br J Dermatol. 1983 Feb;108(2):163-70. doi: 10.1111/j.1365-2133.1983.tb00058.x.

DOI:10.1111/j.1365-2133.1983.tb00058.x

Abstract

Laminin, type IV and type V collagen were localized in twenty-five basal cell carcinomas (BCCs) by immunofluorescence. All basal cell carcinomas were separated from the connective tissue by a continuous basement membrane (BM) which always contained the three antigenic determinants. Nodular and cystic BCCs, but not pagetoid BCCs, contain linear and globular deposits of these BM components. The linear deposits probably represent BM debris that remains undigested and the globular deposits correspond to residual cytoplasmic fragments occurring during apoptosis. These results suggest that BM components are synthesized by epithelial cells and are secreted to polymerize at the dermo-epidermal junction.

摘要

通过免疫荧光法在25例基底细胞癌（BCC）中定位了层粘连蛋白、IV型和V型胶原蛋白。所有基底细胞癌均通过连续的基底膜（BM）与结缔组织分隔开，该基底膜始终包含这三种抗原决定簇。结节性和囊性基底细胞癌，但不包括派杰样基底细胞癌，含有这些基底膜成分的线性和球状沉积物。线性沉积物可能代表未被消化的基底膜碎片，而球状沉积物对应于细胞凋亡过程中出现的残留细胞质片段。这些结果表明，基底膜成分由上皮细胞合成并分泌，在真皮-表皮交界处聚合。