Eickhoff J H, Buchardt Hansen H J, Brommé A, Ericsson B F, Kordt K F, Mouritzen C, Myhre H O, Norgren L, Rostad H, Trippestad A
Br J Surg. 1983 Feb;70(2):85-8. doi: 10.1002/bjs.1800700210.
PTFE (Goretex) and modified human umbilical vein (Biograft) vascular grafts were compared in femorodistal popliteal artery bypass surgery in a randomized clinical multicentre trial. During 18 months 104 patients (104 limbs) entered the trial. Twenty-five patients suffered from claudication, 54 suffered rest pain and 25 patients had ulceration or gangrene. The median preoperative ankle-arm blood pressure index was 0 . 34. Twenty-three limbs had 3 patent tibial arteries, 45 limbs had 2 tibial arteries, 31 limbs had 1 tibial artery while 5 limbs had an isolated popliteal segment. Thirty-six of the operations were redo-operations. Fifty-four patients were allocated to PTFE and 50 to umbilical vein. During follow-up (maximum 650 days) 24 PTFE grafts occluded against 12 umbilical veins. The 1-year patency rate was 40 per cent in the PTFE group against 75 per cent in the umbilical vein group (P = 0 . 014, Gehans test). During the first year the PTFE failure rate was on average 3 . 1 times higher than that of the umbilical vein.
在一项随机临床多中心试验中，对聚四氟乙烯（戈尔特斯）和改良人脐静脉（生物移植）血管移植物在股腘动脉旁路手术中的应用进行了比较。在18个月期间，104例患者（104条肢体）进入试验。25例患者患有间歇性跛行，54例患者有静息痛，25例患者有溃疡或坏疽。术前踝臂血压指数中位数为0.34。23条肢体有3条胫动脉通畅，45条肢体有2条胫动脉通畅，31条肢体有1条胫动脉通畅，而5条肢体仅有腘动脉段。36例手术为再次手术。54例患者被分配接受聚四氟乙烯移植物，50例接受脐静脉移植物。在随访期间（最长650天），24条聚四氟乙烯移植物闭塞，而脐静脉移植物有12条闭塞。聚四氟乙烯组1年通畅率为40%，脐静脉组为75%（P = 0.014，盖汉检验）。在第一年，聚四氟乙烯的失败率平均比脐静脉高3.1倍。
