Nakhooda A F, Poussier P, Marliss E B
Diabetologia. 1983 Jan;24(1):58-62. doi: 10.1007/BF00275949.
Glucose tolerance and insulin secretion were studied in non-diabetic littermates (n = 154) of BB diabetic rats, aged 4-6 months. Initial screening involved two intraperitoneal glucose tolerance tests (0.2 g/100 g body weight) performed one week apart. Nineteen rats (12%) were found to have impaired tolerance which persisted in 14 (74%) (group 1) and was transient in five animals (group 2). Seven rats progressed to overt diabetes in group 1, but none in group 2. Group 1 was characterized by (a) sustained abnormalities in glucose response to oral and intraperitoneal glucose, as well as intraperitoneal tolbutamide and arginine; (b) fasting hypoinsulinaemia; (c) decreased insulin response to glucose and tolbutamide; (d) suppression of the early and late phases of immunoreactive insulin response to intravenous glucose; (e) no systematic abnormalities in glucagon secretion; and (f) the presence of significant insulitis. The group 2 rats had (a) normal glycaemic response to oral and intraperitoneal glucose, tolbutamide and arginine on further testing; (b) normal fasting insulin but excessive insulin response to glucose and tolbutamide, but not to arginine, and (c) mainly normal islet morphology. Thus, impaired glucose tolerance may occur in BB rats with either hypoinsulinaemia or hyperinsulinaemia.
对4至6月龄的BB糖尿病大鼠的非糖尿病同窝仔鼠（n = 154）进行了葡萄糖耐量和胰岛素分泌研究。初始筛查包括间隔一周进行的两次腹腔内葡萄糖耐量试验（0.2 g/100 g体重）。发现19只大鼠（12%）糖耐量受损，其中14只（74%）持续受损（第1组），5只动物糖耐量受损为短暂性（第2组）。第1组中有7只大鼠进展为显性糖尿病，而第2组中无一只进展为显性糖尿病。第1组的特征为：（a）口服和腹腔内给予葡萄糖、腹腔内给予甲苯磺丁脲和精氨酸后，葡萄糖反应持续异常；（b）空腹低胰岛素血症；（c）对葡萄糖和甲苯磺丁脲的胰岛素反应降低；（d）静脉注射葡萄糖后免疫反应性胰岛素反应的早期和晚期受到抑制；（e）胰高血糖素分泌无系统性异常；（f）存在明显的胰岛炎。第2组大鼠具有以下特点：（a）进一步检测时，对口服和腹腔内葡萄糖、甲苯磺丁脲和精氨酸的血糖反应正常；（b）空腹胰岛素正常，但对葡萄糖和甲苯磺丁脲的胰岛素反应过度，但对精氨酸无反应；（c）胰岛形态主要正常。因此，低胰岛素血症或高胰岛素血症的BB大鼠均可能出现糖耐量受损。
