Shornick J K, Bangert J L, Freeman R G, Gilliam J N
J Am Acad Dermatol. 1983 Feb;8(2):214-24. doi: 10.1016/s0190-9622(83)70027-7.
We have studied 28 patients with well-documented herpes gestationis (HG) to determine the frequency of complications and to review the histopathology, immunopathology, and clinical parameters of disease. The frequency of miscarriages and other maternal complications in our series was not extraordinary. Fetal complications were similarly limited. Less than 5% of infants had cutaneous lesions, and no other untoward fetal complications were apparent. Although the clinical features of our patients largely paralleled those typically reported for patients with HG, several variants of disease were noted. We report one woman with immunofluorescence-confirmed HG who had no clinical disease during a subsequent pregnancy. We also identified cases in which the characteristic vesiculobullous lesions of HG never developed. Instead, four women had urticarial papules or plaques throughout their clinical courses. HG was verified in these four women by typical immunofluorescent findings and by recurrent, classical disease during subsequent pregnancies in two. In addition, two women were identified with recurrent HG during pregnancies by different husbands.
我们研究了28例有充分记录的妊娠疱疹（HG）患者，以确定并发症的发生率，并回顾疾病的组织病理学、免疫病理学和临床参数。我们系列中的流产及其他母体并发症发生率并无异常。胎儿并发症同样有限。不到5%的婴儿有皮肤病变，且未发现其他不良胎儿并发症。尽管我们患者的临床特征与HG患者通常报道的大致相似，但仍注意到疾病的几种变体。我们报告了一名经免疫荧光证实为HG的女性，她在随后的妊娠期间没有临床疾病。我们还发现了一些病例，其中HG典型的水疱大疱性病变从未出现。相反，有四名女性在整个病程中出现了荨麻疹丘疹或斑块。这四名女性通过典型的免疫荧光结果以及其中两名女性在随后妊娠期间复发的典型疾病，被证实患有HG。此外，还发现两名女性在与不同丈夫的妊娠期间复发了HG。
