在鼠伤寒沙门氏菌/哺乳动物微粒体试验中对单环芳香胺N-甲基氨基-2-硝基-4-N'，N'-双（2-羟乙基）氨基苯的致突变性评估。

Mutagenic evaluation of the monocyclic aromatic amine N-methylamino-2-nitro-4-N', N'-bis(2-hydroxyethyl)-aminobenzene in the Salmonella typhimurium/mammalian microsome test.

作者信息

Shahin M M, Bugaut A

出版信息

Mutat Res. 1983 Feb;116(2):155-9. doi: 10.1016/0165-1218(83)90106-4.

Abstract

The hair-dye component N-methylamino-2-nitro-4-N', N'-bis(2-hydroxyethyl) aminobenzene was investigated for mutagenic activity in Salmonella typhimurium strains TA1535, TA100, TA1537, TA1538 and TA98. The testing was performed in the absence and in the presence of a rat-liver microsomal activation system induced by Aroclor 1254. Our results indicate that N-methylamino-2-nitro-4-N', N'-bis(2-hydroxyethyl)aminobenzene does not induce mutations in Salmonella typhimurium strains, either in the absence or in the presence of the metabolic activation system. The purity of the compound was controlled by utilizing high-pressure liquid chromatography (HPLC) and thin-layer chromatography (TLC).

摘要

对染发剂成分N-甲基氨基-2-硝基-4-N'，N'-双（2-羟乙基）氨基苯在鼠伤寒沙门氏菌TA1535、TA100、TA1537、TA1538和TA98菌株中进行了致突变活性研究。测试在不存在和存在由多氯联苯混合物Aroclor 1254诱导的大鼠肝微粒体激活系统的情况下进行。我们的结果表明，无论在不存在还是存在代谢激活系统的情况下，N-甲基氨基-2-硝基-4-N'，N'-双（2-羟乙基）氨基苯都不会在鼠伤寒沙门氏菌菌株中诱导突变。通过高压液相色谱法（HPLC）和薄层色谱法（TLC）控制化合物的纯度。