Loprieno N, Mariani L, Rusciano D
Mutat Res. 1983 Feb;116(2):161-8. doi: 10.1016/0165-1218(83)90107-6.
N-Methyl-amino-2-nitro-4-N',N'-bis-(2-hydroxyethyl)-aminobenzene is a hair-dye ingredient. Its potential ability to induce gene mutations, in the yeast S. pombe and in cultured mammalian CH-V79 cells, mitotic gene conversion in the yeast S. cerevisiae, and unscheduled DNA synthesis in cultured human HeLa cells was evaluated. The chemical proved unable to induce detectable genotoxic effects according to these tests. The present data, together with others that show that the chemical is not mutagenic in Salmonella typhimurium or Drosophila, and is not clastogenic in mammalian cytogenetic assays (in vitro or in vivo), strongly support the non-genotoxicity of the chemical.
N-甲基氨基-2-硝基-4-N'，N'-双（2-羟乙基）氨基苯是一种染发剂成分。评估了其在粟酒裂殖酵母和培养的哺乳动物CH-V79细胞中诱导基因突变的潜在能力、在酿酒酵母中的有丝分裂基因转换能力以及在培养的人HeLa细胞中的非预定DNA合成能力。根据这些测试，该化学物质被证明无法诱导可检测到的遗传毒性效应。目前的数据，以及其他表明该化学物质在鼠伤寒沙门氏菌或果蝇中不具有致突变性，且在哺乳动物细胞遗传学试验（体外或体内）中不具有染色体断裂作用的数据，有力地支持了该化学物质的非遗传毒性。
