Scheible W, James H E, Leopold G R, Hilton S V
Radiology. 1983 Mar;146(3):743-6. doi: 10.1148/radiology.146.3.6338558.
Spinal dysraphism refers to incomplete embryologic development of the dorsal midline. Frequently it is not clinically obvious, and lack of treatment can lead to progressive neurological damage. Early diagnosis of occult defects can allow appropriate surgical intervention and prevent neurological deficits. The authors have used high-resolution real-time ultrasound to screen infants with various cutaneous lumbosacral markers, all of whom were at risk of occult spinal dysraphism. Preliminary results suggest that ultrasound is a reliable screening procedure and could obviate the need for more costly and invasive tests.
脊柱裂是指背侧中线胚胎发育不完全。通常在临床上并不明显，未经治疗可能会导致进行性神经损伤。隐匿性缺陷的早期诊断可进行适当的手术干预并预防神经功能缺损。作者使用高分辨率实时超声对有各种腰骶部皮肤标志物的婴儿进行筛查，这些婴儿均有隐匿性脊柱裂的风险。初步结果表明，超声是一种可靠的筛查方法，可避免进行成本更高且具有侵入性的检查。
