Whelchel J D, Alison D V, Luke R G, Curtis J, Diethelm A G
Transplantation. 1983 Feb;35(2):161-4. doi: 10.1097/00007890-198302000-00010.
Two patients with documented primary hyperoxaluria have received renal allografts with successful function for 10 years and 25 months. The patient in case 1 required a ureterolithotomy 6 years post-transplantation to remove a renal calculus of calcium oxalate. This case illustrates that despite recurrence of oxalate stones in the allograft, satisfactory renal function can be maintained by careful follow-up and appropriate interventions. Factors that may be important in successful graft function include the occurrence of acute rejection episodes, avoidance of ischemic graft damage, trials of pyridoxine therapy to decrease oxalate excretion, and frequent evaluation with appropriate interventions as necessary. Renal transplantation is a suitable and possibly the preferred form of therapy of end stage renal disease in patients with primary hyperoxaluria.
两名确诊为原发性高草酸尿症的患者接受了同种异体肾移植，移植肾功能分别成功维持了10年和25个月。病例1中的患者在移植后6年需要进行输尿管切开取石术，以取出草酸钙肾结石。该病例表明，尽管同种异体移植肾中草酸盐结石复发，但通过仔细随访和适当干预，仍可维持满意的肾功能。对于移植肾功能成功可能重要的因素包括急性排斥反应的发生、避免移植肾缺血性损伤、尝试使用维生素B6治疗以减少草酸盐排泄，以及必要时进行频繁评估并采取适当干预措施。肾移植是原发性高草酸尿症患者终末期肾病合适且可能是首选的治疗方式。
