Olsen M E, Faber O K, Binder C
Acta Endocrinol (Copenh). 1983 Mar;102(3):416-9. doi: 10.1530/acta.0.1020416.
Peripheral venous plasma insulin and C-peptide concentrations during oral glucose tolerance tests were measured in 7 normal weight non-diabetic subjects before and after 7 days of sucrose hyperalimentation. This induced a deterioration of the glucose tolerance with higher levels of glucose, insulin and C-peptide. The C-peptide to insulin molar ratio as well as the relation between incremental areas under the plasma curves of the two peptides were used as relative measures of the hepatic insulin extraction. Both estimates of hepatic insulin extraction were unchanged by hyperalimentation, suggesting that the induced decreases in glucose tolerance and insulin receptor function are not followed by a decrease in hepatic insulin extraction as found in obese subjects with similar changes in glucose tolerance and insulin receptor function.
在7名体重正常的非糖尿病受试者中，测量了口服葡萄糖耐量试验期间外周静脉血浆胰岛素和C肽浓度，分别在蔗糖高营养支持7天前后进行。这导致葡萄糖耐量恶化，血糖、胰岛素和C肽水平升高。C肽与胰岛素的摩尔比以及两种肽的血浆曲线下增量面积之间的关系被用作肝脏胰岛素提取的相对指标。高营养支持并未改变肝脏胰岛素提取的这两种评估结果，这表明在葡萄糖耐量和胰岛素受体功能发生类似变化的肥胖受试者中所发现的情况不同，即葡萄糖耐量和胰岛素受体功能的诱导性降低之后，肝脏胰岛素提取并未减少。
