Köhler H, Schröter-Printzen I, Nustede R, Barthel M, Ebert R, Schafmayer A
Department of General Surgery, University of Göttingen, FRG.
Int J Pancreatol. 1992 Apr;11(2):117-24. doi: 10.1007/BF02925983.
The functional connection between the gut and the islet cells comprises nerves and gastrointestinal hormones. In this study, we quantified the incretin effect and the glucose tolerance (KG value) before and after denervation of the pancreas in dogs in order to find out whether the incretin effect is mediated by nerves. The participation of nerves was estimated by comparing metabolic tests before and after total extrinsic pancreatic denervation in 10 dogs. Fifty-nine percent of the insulin response after intragastric glucose was calculated preoperatively to be the result of incretin factors, a value similar to the 62% found in the postoperative series (with denervated pancreas). The response of GIP to intragastric glucose was not significantly different between pre- and postoperative tests. The KG values pre- and postoperative were in the same range. From our data, we conclude that extrinsic nerves of the pancreas do not seem to play an important role in mediating glucose homeostasis in dogs.
肠道与胰岛细胞之间的功能联系包括神经和胃肠激素。在本研究中，我们对犬胰腺去神经前后的肠促胰岛素效应和葡萄糖耐量（KG值）进行了量化，以确定肠促胰岛素效应是否由神经介导。通过比较10只犬胰腺完全去神经前后的代谢测试来评估神经的参与情况。术前计算出胃内给予葡萄糖后胰岛素反应的59%是由肠促胰岛素因子所致，这一数值与术后系列（胰腺去神经）中发现的62%相似。术前和术后测试中，胃内给予葡萄糖后GIP的反应无显著差异。术前和术后的KG值处于相同范围。根据我们的数据，我们得出结论，胰腺的外在神经似乎在介导犬的葡萄糖稳态方面并不起重要作用。
