Hansen F M, Nilsson P, Hustvedt B E, Nilsson-Ehle P, Løvø A
Am J Physiol. 1983 Mar;244(3):E203-8. doi: 10.1152/ajpendo.1983.244.3.E203.
The significance of the hyperinsulinemia on the altered metabolism in ventromedial hypothalamus (VMH)-lesioned rats was tested. VMH lesions induced increases in fatty acid synthesis, lipoprotein lipase (LPL) activity, and plasma urea levels, and a decrease in plasma triglyceride concentrations. Similarly, in normal rats treated with pharmacological doses of insulin (14 U X rat-1 X day-1), fatty acid synthesis and LPL activity in fat tissue and the plasma urea were considerably elevated and plasma triglyceride was lowered compared with untreated controls. When endogenous insulin production was abolished by streptozotocin treatment, the four metabolic variables in the VMH-lesioned rats did not differ from those in diabetic controls. Substitution with 2 U of insulin X rat-1 X day-1, however, restored the differences in metabolism between VMH-lesioned diabetic and control diabetic rats. Substitution with 3 or 4 U insulin X rat-1 X day-1 showed the same differences. In VMH-lesioned rats the insulin level increased significantly from the 10th to the 70th day postoperatively; however, the rate of fatty acid synthesis, LPL activity, and plasma urea levels decreased, whereas plasma triglyceride concentrations increased. The results strongly suggest that the metabolic changes occurring after VMH lesions are only in part explained by the hyperinsulinemia associated with the VMH syndrome and indicate that other hormonal and/or nervous factors are involved.
本研究检测了高胰岛素血症对腹内侧下丘脑（VMH）损伤大鼠代谢改变的影响。VMH损伤可导致脂肪酸合成增加、脂蛋白脂肪酶（LPL）活性升高以及血浆尿素水平升高，同时血浆甘油三酯浓度降低。同样，在用药理剂量胰岛素（14 U·大鼠⁻¹·天⁻¹）处理的正常大鼠中，脂肪组织中的脂肪酸合成和LPL活性以及血浆尿素水平显著升高，而血浆甘油三酯水平则低于未处理的对照组。当通过链脲佐菌素处理消除内源性胰岛素分泌时，VMH损伤大鼠的这四个代谢变量与糖尿病对照组并无差异。然而，用2 U·大鼠⁻¹·天⁻¹的胰岛素替代治疗，恢复了VMH损伤糖尿病大鼠与对照糖尿病大鼠之间的代谢差异。用3或4 U·大鼠⁻¹·天⁻¹的胰岛素替代治疗也显示出相同的差异。在VMH损伤大鼠中，胰岛素水平在术后第10天至第70天显著升高；然而，脂肪酸合成速率、LPL活性和血浆尿素水平降低，而血浆甘油三酯浓度升高。结果强烈表明，VMH损伤后发生的代谢变化仅部分由与VMH综合征相关的高胰岛素血症所解释，这表明其他激素和/或神经因素也参与其中。
