Ferrario F, Kourilsky O, Morel-Maroger L
Clin Nephrol. 1983 Jan;19(1):17-23.
30 renal biopsies were performed in 20 adult patients with acute diffuse endocapillary glomerulonephritis. 11 patients who presented with acute renal failure (ARF) and 9 patients who had normal or mildly altered renal function were compared in order to look for clinical or pathologic features peculiar to each group and possible differences in outcome. All patients underwent early renal biopsy, and 8 had repeat biopsies. There were no significant differences in clinical, immunologic or histologic features between the two groups. In repeat biopsies, there were no histologic nor immunohistologic differences between patients with or without initial ARF. After a mean follow-up period of 18 months, the overall clinical outcome appeared favorable and was similar in the two groups. Thus, initial ARF in patients with acute endocapillary glomerulonephritis does not imply a bad prognosis. The recognition of pure endocapillary proliferation in patients with anuric acute glomerulonephritis by means of renal biopsy may avoid unnecessary and potentially hazardous treatment.
对20例成人急性弥漫性毛细血管内增生性肾小球肾炎患者进行了30次肾活检。比较了11例出现急性肾衰竭（ARF）的患者和9例肾功能正常或轻度改变的患者，以寻找每组特有的临床或病理特征以及结局可能存在的差异。所有患者均接受了早期肾活检，其中8例进行了重复活检。两组在临床、免疫或组织学特征方面无显著差异。在重复活检中，初始有或无ARF的患者在组织学和免疫组织学上均无差异。平均随访18个月后，总体临床结局良好，两组相似。因此，急性毛细血管内增生性肾小球肾炎患者初始出现ARF并不意味着预后不良。通过肾活检识别无尿性急性肾小球肾炎患者的单纯毛细血管内增生，可避免不必要的和潜在危险的治疗。
