Asplin C M, Werner P L, Halter J B, Hollander P M, Palmer J P
Endocrinology. 1983 May;112(5):1585-9. doi: 10.1210/endo-112-5-1585.
The role which the autonomic nervous system (ANS) plays in controlling glucagon (IRG) secretion is controversial. Strong activation of the ANS was achieved in baboons with 500 mg/kg 2-deoxyglucose, producing a 20-fold rise in epinephrine and a 15-fold rise in IRG. Under such circumstances, the IRG response was attenuated by both alpha- and beta-adrenergic blockade, strongly suggesting that this part of the IRG rise post 2-deoxyglucose was mediated via adrenergic mechanisms. The baboon is similar to man, with the sympatho-adrenal axis having little influence on IRG secretion during mild activation of the ANS. However, during stronger ANS activation with 2-deoxyglucose, a clear effect of the sympatho-adrenal axis on IRG secretion was demonstrated. Whether experiments in primates demonstrate an effect of the ANS on IRG secretion may depend primarily on the strength of the neural response elicted.
自主神经系统（ANS）在控制胰高血糖素（IRG）分泌中所起的作用存在争议。给狒狒注射500mg/kg的2-脱氧葡萄糖可实现对ANS的强烈激活，使肾上腺素升高20倍，IRG升高15倍。在这种情况下，α和β肾上腺素能阻滞剂均可减弱IRG反应，强烈提示2-脱氧葡萄糖后IRG升高的这部分是通过肾上腺素能机制介导的。狒狒与人类相似，在ANS轻度激活期间，交感-肾上腺轴对IRG分泌影响很小。然而，在用2-脱氧葡萄糖进行更强的ANS激活时，交感-肾上腺轴对IRG分泌有明显影响。灵长类动物实验是否证明ANS对IRG分泌有影响可能主要取决于所引发的神经反应强度。
