6-和7-[2-(5-羧基咪唑-4-甲酰胺基)苯乙酰胺基]青霉素和头孢菌素的合成及抗菌活性
Synthesis and antibacterial activity of 6- and 7-[2-(5-carboxyimidazole-4-carboxamido)phenylacetamido]-penicillins and cephalosporins.
作者信息
Yasuda N, Iwagami H, Nakanishi E, Nakamiya T, Sasaki Y, Murata T
出版信息
J Antibiot (Tokyo). 1983 Mar;36(3):242-9. doi: 10.7164/antibiotics.36.242.
PMID:6339459
Abstract
The synthesis and antibacterial activity of a series of beta-lactam antibiotics having a 5-carboxyimidazole-4-carbonyl group attached through an amide linkage to ampicillin, cephaloglycin or their analogs are described. Some compounds of this series were found to possess high activity against Pseudomonas and other Gram-negative bacteria.
摘要
描述了一系列通过酰胺键连接到氨苄青霉素、头孢甘氨酸或其类似物上的具有5-羧基咪唑-4-羰基的β-内酰胺抗生素的合成及其抗菌活性。发现该系列中的一些化合物对假单胞菌和其他革兰氏阴性菌具有高活性。
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