• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

6-和7-[2-(5-羧基咪唑-4-甲酰胺基)苯乙酰胺基]青霉素和头孢菌素的合成及抗菌活性

Synthesis and antibacterial activity of 6- and 7-[2-(5-carboxyimidazole-4-carboxamido)phenylacetamido]-penicillins and cephalosporins.

作者信息

Yasuda N, Iwagami H, Nakanishi E, Nakamiya T, Sasaki Y, Murata T

出版信息

J Antibiot (Tokyo). 1983 Mar;36(3):242-9. doi: 10.7164/antibiotics.36.242.

DOI:10.7164/antibiotics.36.242
PMID:6339459
Abstract

The synthesis and antibacterial activity of a series of beta-lactam antibiotics having a 5-carboxyimidazole-4-carbonyl group attached through an amide linkage to ampicillin, cephaloglycin or their analogs are described. Some compounds of this series were found to possess high activity against Pseudomonas and other Gram-negative bacteria.

摘要

描述了一系列通过酰胺键连接到氨苄青霉素、头孢甘氨酸或其类似物上的具有5-羧基咪唑-4-羰基的β-内酰胺抗生素的合成及其抗菌活性。发现该系列中的一些化合物对假单胞菌和其他革兰氏阴性菌具有高活性。

相似文献

1
Synthesis and antibacterial activity of 6- and 7-[2-(5-carboxyimidazole-4-carboxamido)phenylacetamido]-penicillins and cephalosporins.6-和7-[2-(5-羧基咪唑-4-甲酰胺基)苯乙酰胺基]青霉素和头孢菌素的合成及抗菌活性
J Antibiot (Tokyo). 1983 Mar;36(3):242-9. doi: 10.7164/antibiotics.36.242.
2
Differences between cephalothin and newer parenterally absorbed cephalosporins in vitro: a justification for separate disks.
J Infect Dis. 1978 May;137 Suppl:S32-S37. doi: 10.1093/infdis/137.supplement.s32.
3
Susceptibility of "enterobacteria" to penicillins, cephalosporins, lincomycins, erythromycin, and rifampin.“肠杆菌”对青霉素、头孢菌素、林可霉素、红霉素和利福平的敏感性。
J Infect Dis. 1976 Aug;134 Suppl:S75-96. doi: 10.1093/infdis/134.supplement_1.s75.
4
Amoxicillin: in vitro susceptibility of "blood culture strains" of gram-negative bacilli and comparisons with penicillin G ampicillin, and carbenicillin.阿莫西林：革兰氏阴性杆菌“血培养菌株”的体外敏感性及与青霉素G、氨苄西林和羧苄西林的比较。
J Infect Dis. 1974 Jun;129(0):suppl:S132-8. doi: 10.1093/infdis/129.supplement_2.s132.
5
[Evaluation of the antibacterial activity in vitro of various cephalosporins on different gram-negative bacterial species of recent clinical isolation].[近期临床分离的不同革兰氏阴性菌对多种头孢菌素的体外抗菌活性评估]
Boll Soc Ital Biol Sper. 1980 Jan 30;56(2):133-9.
6
Synergism of PS-5 with penicillins and cephalosporins in antimicrobial activity against beta-lactam-resistant gram-negative microorganisms.
J Antibiot (Tokyo). 1984 Nov;37(11):1414-22. doi: 10.7164/antibiotics.37.1414.
7
Drug susceptibility-resistance pattern of gram-negative uropathogens to seven cephalosporins.革兰氏阴性尿路病原体对七种头孢菌素的药敏-耐药模式
Am J Med Sci. 1973 Nov;266(5):381-5. doi: 10.1097/00000441-197311000-00005.
8
[Gentamicin susceptibility of gram-negative problem germs and staphylococci, indicated by the tube dilution method].[采用试管稀释法测定革兰氏阴性问题病原菌和葡萄球菌对庆大霉素的敏感性]
Pathol Microbiol (Basel). 1972;38(4):286-95.
9
Combined action of beta-lactum antibiotics against gram-negative bacilli.β-内酰胺类抗生素对革兰氏阴性杆菌的联合作用。
J Hyg Epidemiol Microbiol Immunol. 1973;17(2):129-40.
10
Chemistry of cephalosporin antibiotics. 28. Preparation and biological activity of 3-(substituted)vinyl cephalosporins.
J Med Chem. 1975 Oct;18(10):986-92. doi: 10.1021/jm00244a007.

引用本文的文献

1
Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus.靶向登革热病毒和黄热病病毒的咪唑-4,5-二羧酸酰胺及吡嗪-2,3-二羧酸酰胺的合成与评估
Eur J Med Chem. 2014 Nov 24;87:529-39. doi: 10.1016/j.ejmech.2014.09.062. Epub 2014 Sep 22.
2
Pharmacokinetics of cefpimizole in normal humans after single- and multiple-dose intravenous infusions.头孢咪唑在正常人体单次及多次静脉滴注后的药代动力学。
Antimicrob Agents Chemother. 1984 Dec;26(6):802-6. doi: 10.1128/AAC.26.6.802.
3
In vitro comparative antimicrobial activity of cefpimizole against clinical isolates from five medical centers.
头孢咪唑对来自五个医学中心的临床分离株的体外比较抗菌活性。
Antimicrob Agents Chemother. 1985 Jun;27(6):982-4. doi: 10.1128/AAC.27.6.982.
4
Pharmacokinetics and dose proportionality of cefpimizole in normal humans after intramuscular administration.头孢咪唑在正常人体内肌肉注射后的药代动力学及剂量比例关系
Antimicrob Agents Chemother. 1986 Feb;29(2):271-7. doi: 10.1128/AAC.29.2.271.
5
Tolerance and disposition of cefpimizole in normal human volunteers after intramuscular administration.头孢咪唑在正常人体志愿者肌肉注射后的耐受性及处置情况。
Antimicrob Agents Chemother. 1987 Nov;31(11):1706-10. doi: 10.1128/AAC.31.11.1706.