Piccolomini R, Di Sipio L, Ravagnan G
Boll Soc Ital Biol Sper. 1980 Jan 30;56(2):133-9.
The Authors have compared the antibacterial activity "in vitro" of new cephalosporines (cephuroxim, cephoxitin and cephaclor) with other cephalosporines having an action which is already known (cephaloridine, cephazoline and cephalexine) on the Gram-negative bacterial strains of recent clinical isolation. The results show that the cephalosporines of last generation, having in their molecular nucleus a methoximinic group, realize a greater antibacterial protection than those cephalosporines of antecedent preparation.
作者们比较了新型头孢菌素(头孢呋辛、头孢西丁和头孢克洛)与其他已知有抗菌作用的头孢菌素(头孢噻啶、头孢唑林和头孢氨苄)对近期临床分离的革兰氏阴性菌菌株的“体外”抗菌活性。结果表明,分子核中含有甲肟基的新一代头孢菌素比先前制剂的头孢菌素具有更强的抗菌保护作用。