前列腺素I2（PG I2）和血栓素A2（TXA2）合成酶抑制剂（OKY - 1581）对妊娠犬血流动力学影响的比较研究。

Comparative study of prostaglandin I2 (PG I2) and thromboxane A2 (TXA2) synthetase inhibitor (OKY-1581) on hemodynamics in pregnant dogs.

作者信息

Murayama K, Kasai H, Adachi T, Utsunomiya O, Ouchi H

出版信息

Nihon Sanka Fujinka Gakkai Zasshi. 1983 Mar;35(3):344-50.

Abstract

Effects of intravenous injections of prostaglandin I2 (PG I2) and thromboxane A2 (TXA2) synthetase inhibitor (OKY-1581) on mean arterial pressure (MAP), cardiac output (CO), heart rate (HR), renal blood flow (RBF), and uterine blood flow (UBF) were investigated in the anesthetized pregnant dog. A dose-dependent fall in MAP was observed with these two agents. HR was almost unchanged by both PG I2 and TXA2 synthetase inhibitor. PG I2 and TXA2 synthetase inhibitor produced increases in CO and RBF in a dose-dependent manner. PG I2 caused a dose-dependent decrease in UBF, while TXA2 synthetase inhibitor was followed by an insignificant decrease in UBF. PG I2 and TXA2 synthetase inhibitor did not induce any increase in intrauterine pressure (IUP). The possibility of treatment of pregnancy-induced hypertension with PG I2 or TXA2 synthetase inhibitor is discussed.

摘要

在麻醉的妊娠犬中，研究了静脉注射前列腺素I2（PG I2）和血栓素A2（TXA2）合成酶抑制剂（OKY - 1581）对平均动脉压（MAP）、心输出量（CO）、心率（HR）、肾血流量（RBF）和子宫血流量（UBF）的影响。观察到这两种药物使MAP呈剂量依赖性下降。PG I2和TXA2合成酶抑制剂对HR几乎没有影响。PG I2和TXA2合成酶抑制剂使CO和RBF呈剂量依赖性增加。PG I2使UBF呈剂量依赖性降低，而TXA2合成酶抑制剂使UBF有不显著的降低。PG I2和TXA2合成酶抑制剂未引起子宫内压（IUP）升高。讨论了用PG I2或TXA2合成酶抑制剂治疗妊娠高血压的可能性。