Pollock R A, Britt B A
Laryngoscope. 1983 Mar;93(3):318-25. doi: 10.1288/00005537-198303000-00015.
Malignant hyperthermia, a disorder often initiated by exposure to a variety of anesthetic agents, continues to be of major importance to the head and neck surgeon because: 1. approximately 40% of all reported reactions have occurred during anesthesia for head and neck surgery; 2. the possibility of mortality still exists despite the use of new pharmacologic agents, such as dantrolene; and, 3. subtle variations in the intraoperative and postoperative presentation of malignant hyperthermia are being increasingly recognized and treated. The authors briefly tabulate the 280 cases--which have occurred worldwide during otolaryngologic, dental, facial plastic, ophthalmologic and neurosurgical procedures--that are registered with the Department of Anaesthesia, University of Toronto, Canada. A case report depicting a less-than-typical reaction is presented. The authors emphasize that early recognition of the clinical features of an ongoing reaction, whether mild or severe, is by far the most important factor in reducing morbidity and mortality of patients who suffer hyperthermic crises while undergoing head and neck surgery.
恶性高热是一种常由接触多种麻醉剂引发的疾病,对于头颈外科医生而言仍然至关重要,原因如下:1. 所有报告的反应中约40%发生在头颈外科手术的麻醉期间;2. 尽管使用了新的药物如丹曲林,死亡可能性仍然存在;3. 恶性高热在术中及术后表现的细微差异正日益得到认识和治疗。作者简要列出了在加拿大多伦多大学麻醉科登记的、发生在全球范围内耳鼻喉科、牙科、面部整形、眼科和神经外科手术中的280例病例。并呈现了一份描述不太典型反应的病例报告。作者强调,尽早识别正在发生的反应的临床特征,无论反应轻微还是严重,是降低接受头颈外科手术时发生高热危象患者的发病率和死亡率的最重要因素。