Sorosky J I, Ingardia C J, Botti J J
Department of Obstetrics and Gynecology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Am J Perinatol. 1989 Jan;6(1):46-8. doi: 10.1055/s-2007-999543.
A case of susceptibility to malignant hyperthermia, diagnosed by muscle biopsy during the first trimester of pregnancy, is presented. Pertinent medical history that might raise this suspicion is reviewed. The pathophysiology of malignant hyperthermia is discussed. Recent reports documenting the placental transfer of dantrolene and complications associated with dantrolene administration during labor are described. The pharmacology of dantrolene sodium is presented. Guidelines regarding the management of labor and delivery in patients susceptible to malignant hyperthermia are outlined. Suggestions for counseling patients and their children with this syndrome are reviewed.
本文介绍了一例在妊娠早期通过肌肉活检诊断出的恶性高热易感性病例。回顾了可能引发这种怀疑的相关病史。讨论了恶性高热的病理生理学。描述了近期关于丹曲林胎盘转运以及分娩期间使用丹曲林相关并发症的报告。介绍了丹曲林钠的药理学。概述了恶性高热易感患者分娩管理的指南。回顾了为患有该综合征的患者及其子女提供咨询的建议。
