Nakamura A, Tateno N, Iwata T, Kojima S, Kaniwa M, Kawamura T
Mutat Res. 1983 Apr;117(1-2):1-8. doi: 10.1016/0165-1218(83)90147-7.
The mutagenicity of pure synthesized samples of bis(2,3-dibromopropyl)phosphate (bis-BP) and mono(2,3-dibromopropyl)phosphate (mono-BP) against Salmonella typhimurium TA100 was examined in relation to microsomal activation of tris(2,3-dibromopropyl)phosphate (tris-BP). Both mono- and bis-BPs were weak direct mutagens. Their mutagenicities increased with S9 mix, but the rates were much less than that of tris-BP. The magnesium and ammonium salts of mono- and bis-BPs were also prepared and their mutagenicities were examined with S9 mix in relation to 2 commercial flame retardants (our abbreviations: DB-1 and DB-2). In both mono- and bis-BP series, an apparent increase of mutagenicity was observed in the order: ammonium salt greater than magnesium salt greater than free acid. On the other hand, mono-BP and its salts are usually more active than the corresponding bis-BPs independently of the kind of cation. DB-1 (DB-2), however, is more potent than the magnesium (ammonium) salts of mono- and bis-BPs, the constituents in DB-1 (DB-2). No synergistic effect between mono-BP salts and bis-BP salts was observed. The different unknown mutagenic compounds in DB-1 and DB-2 are suggested.
研究了磷酸双（2,3 - 二溴丙基）酯（双 - BP）和磷酸单（2,3 - 二溴丙基）酯（单 - BP）纯合成样品对鼠伤寒沙门氏菌TA100的致突变性，并与磷酸三（2,3 - 二溴丙基）酯（三 - BP）的微粒体活化作用相关联。单 - BP和双 - BP都是弱直接致突变剂。它们的致突变性随S9混合液而增加，但增加速率远低于三 - BP。还制备了单 - BP和双 - BP的镁盐和铵盐，并在S9混合液存在下，针对两种市售阻燃剂（我们的缩写：DB - 1和DB - 2）对它们的致突变性进行了检测。在单 - BP和双 - BP系列中，均观察到致突变性明显增加，顺序为：铵盐大于镁盐大于游离酸。另一方面，单 - BP及其盐类通常比相应的双 - BP更具活性，与阳离子种类无关。然而，DB - 1（DB - 2）比单 - BP和双 - BP的镁（铵）盐更具效力，而DB - 1（DB - 2）中的成分正是这些盐类。未观察到单 - BP盐类和双 - BP盐类之间的协同效应。文中还提出了DB - 1和DB - 2中不同的未知致突变化合物。
