Zeiger E, Pagano D A, Nomeir A A
Environ Mutagen. 1982;4(3):271-7. doi: 10.1002/em.2860040310.
A series of methylated metabolites of the flame retardant tris(2,3-dibromopropyl) phosphate (Tris-BP) were tested for mutagenicity in Salmonella, along with the parent chemical and other structurally related chemicals. The metabolites produced a gradient of mutagenic responses in TA1535 in the same dose range and up to the same magnitude as the Tris-BP response. None of the metabolites tested appeared to be the ultimate mutagen, since they all required S-9 for their mutagenic activity.
对阻燃剂磷酸三（2,3 - 二溴丙基）酯（Tris - BP）的一系列甲基化代谢物以及母体化合物和其他结构相关化合物进行了沙门氏菌致突变性测试。在相同剂量范围内，这些代谢物在TA1535中产生了一系列致突变反应梯度，且致突变程度与Tris - BP的反应相同。所测试的代谢物似乎都不是最终的致突变物，因为它们的致突变活性都需要S - 9。
