Molenda J, Kozyrczak J, Skurski A, Zwierzchowski J, Staroniewicz Z
Res Vet Sci. 1983 Jan;34(1):1-4.
The protective effects of high levels of O115 antibodies and K88 antibodies in the sera of hyperimmunized rabbits on the intestinal loop dilation elicited by live cultures of Escherichia coli O115: K88:H39 and its enterotoxins were examined. K88 antibodies did not prevent fluid accumulation when live E coli O115:K88:H39 or its enterotoxins were injected into ligated loops in rabbits actively immunised with K12:K88 or when K88 antiserum was mixed directly with the challenge shortly before injection into the loops. In two of six rabbits immunised with heat-killed O115 E coli the live strain failed to elicit a fluid response and in two others the response was reduced. In all cases the O115 antiserum inhibited the fluid response evoked by the live, homologous bacteria, but not by enterotoxin preparations, when the serum was mixed directly with the challenge before injection.
检测了经高度免疫的兔血清中高水平的O115抗体和K88抗体对由大肠杆菌O115:K88:H39活菌培养物及其肠毒素引起的肠袢扩张的保护作用。当将活的大肠杆菌O115:K88:H39或其肠毒素注射到用K12:K88主动免疫的兔的结扎肠袢中时，或者当在将K88抗血清注射到肠袢之前不久将其直接与攻击物混合时，K88抗体不能阻止液体蓄积。在用热灭活的O115大肠杆菌免疫的6只兔中，有2只兔对活菌株未产生液体反应，另外2只兔的反应减弱。在所有情况下，当血清在注射前直接与攻击物混合时，O115抗血清可抑制由活的同源细菌引起的液体反应，但不能抑制肠毒素制剂引起的反应。
