Ruud E, Steen H B, Beiske K, Godal T
Scand J Immunol. 1983 Feb;17(2):155-60. doi: 10.1111/j.1365-3083.1983.tb00778.x.
The effect of anti-Igs in combination with the tumour promotor TPA on DNA and Ig synthesis in a human follicular germinal centre cell lymphoma carrying sIgM and sIgD was investigated. The lymphoma cells responded to both anti-mu and anti-delta chains and to anti-lambda light chains by DNA synthesis, as measured by methyl-(3H)-thymidine incorporation. Flow cytofluorometric measurements, however, showed that only anti-mu chains induced marked increase in cytoplasmic Ig content. This result suggests that in certain B-cell subsets the signals elicited via sIgM and sIgD are different.
研究了抗免疫球蛋白（anti-Igs）与肿瘤促进剂佛波酯（TPA）联合应用对携带表面免疫球蛋白M（sIgM）和表面免疫球蛋白D（sIgD）的人滤泡生发中心细胞淋巴瘤中DNA和免疫球蛋白合成的影响。通过甲基-（3H）-胸腺嘧啶核苷掺入法测定，淋巴瘤细胞对抗μ链、抗δ链以及抗λ轻链均有DNA合成反应。然而，流式细胞荧光测定法显示，只有抗μ链能显著增加细胞质免疫球蛋白含量。这一结果表明，在某些B细胞亚群中，通过sIgM和sIgD引发的信号是不同的。
