Goto T, Abe K, Otsuka Y, Seino M, Ito T, Imai Y, Haruyama T, Sato M, Hiwatari M, Sato K, Omata K, Kasai Y, Tajima J, Yoshinaga K
Tohoku J Exp Med. 1983 Jan;139(1):103-11. doi: 10.1620/tjem.139.103.
The changes in active and inactive renin after oral administration of captopril (SQ 14225) were studied in 29 hypertensive patients. Inactive renin was calculated as plasma renin activity (PRA) after cold storage (total renin) minus PRA before cold storage (active renin). The patients were divided into 2 groups, responders and non-responders, according to the response of active renin to captopril. In 9 responders, the active renin increased markedly, while the inactive renin decreased. On the other hand, in 20 non-responders, both renin activities increased only slightly. Total renin increased markedly in responders; it increased in much smaller degree but significantly in non-responders. These data suggest that captopril promotes the conversion of inactive renin to active one and augments the renin release as a whole.
对29例高血压患者研究了口服卡托普利（SQ 14225）后活性肾素和非活性肾素的变化。非活性肾素通过冷储存后的血浆肾素活性（PRA）（总肾素）减去冷储存前的PRA（活性肾素）来计算。根据活性肾素对卡托普利的反应，将患者分为两组，反应者和无反应者。在9例反应者中，活性肾素显著增加，而非活性肾素减少。另一方面，在20例无反应者中，两种肾素活性仅略有增加。反应者的总肾素显著增加；无反应者的总肾素增加程度小得多，但也有显著增加。这些数据表明，卡托普利促进非活性肾素向活性肾素的转化，并整体上增加肾素释放。
