Goto T, Abe K, Otsuka Y, Itoh T, Imai Y, Satoh M, Omata K, Yoshinaga K
Tohoku J Exp Med. 1980 Nov;132(3):363-4. doi: 10.1620/tjem.132.363.
The changes of active and inactive renin in plasma after the oral administration of 25 mg or 50 mg of SQ 14225 (Captopril) were studied in 29 hypertensive patients. Inactive renin was calculated as plasma renin activity (PRA) after cold storage minus PRA before cold storage. The patients were divided into 2 groups, responders and non-responders, according to the response of active renin to Captopril. In 9 responders, the active renin increased markedly while the inactive renin decreased. On the other hand, in 20 non-responders, both renin activities increased only slightly. These results suggest that inactive renin may be converted in vivo to active renin by Captopril.
在29例高血压患者中研究了口服25毫克或50毫克SQ 14225（卡托普利）后血浆中活性肾素和非活性肾素的变化。非活性肾素通过冷藏后血浆肾素活性（PRA）减去冷藏前的PRA来计算。根据活性肾素对卡托普利的反应，将患者分为两组，反应者和无反应者。在9例反应者中，活性肾素显著增加而非活性肾素减少。另一方面，在20例无反应者中，两种肾素活性仅略有增加。这些结果表明，非活性肾素可能在体内被卡托普利转化为活性肾素。
