Janckila A J, Stelzer G T, Wallace J H, Yam L T
Am J Clin Pathol. 1983 Apr;79(4):431-7. doi: 10.1093/ajcp/79.4.431.
Hairy cell populations of greater than 90 purity were prepared from six samples obtained from four patients with leukemic reticuloendotheliosis (LRE). These then were analyzed for surface immunoglobulin (SIg) and antigens specified by a panel of monoclonal antibodies. The hairy cells from all patients displayed SIg and antigens reactive with OKIa-1 and OKM-1 antibodies; these markers often were expressed simultaneously. T-cell-specific antigens were not displayed on the surface of hairy cells. The simultaneous expression of SIg and OKM-1 which ordinarily are unique for B cells or myeloid cells, respectively, suggests that hairy cells may represent an aberrant form of either cell type with defective regulation of antigen expression. It alternatively suggests the possibility that B cells and myeloid elements develop along a common pathway and that the hairy cell is a component of such a pathway.
从4例白血病性网状内皮细胞增多症（LRE）患者获取的6份样本中制备出纯度大于90%的毛细胞群体。然后对这些毛细胞群体进行表面免疫球蛋白（SIg）和一组单克隆抗体所识别的抗原分析。所有患者的毛细胞均显示出SIg以及与OKIa-1和OKM-1抗体反应的抗原；这些标志物常同时表达。T细胞特异性抗原未在毛细胞表面显示。通常分别对B细胞或髓细胞而言具有独特性的SIg和OKM-1的同时表达提示，毛细胞可能代表这两种细胞类型中某一种的异常形式，其抗原表达调控存在缺陷。这也提示了另一种可能性，即B细胞和髓系成分沿着一条共同途径发育，而毛细胞是该途径的一个组成部分。
