Posnett D N, Chiorazzi N, Kunkel H G
J Clin Invest. 1982 Aug;70(2):254-61. doi: 10.1172/jci110612.
Hairy cell leukemia is a well described clinical entity, but the cell of origin for this leukemic cell and its function are still unknown. There are no totally specific markers for this cell, although tartrate-resistant acid phosphatase staining has been used extensively as a diagnostic test. This study describes three monoclonal murine antibodies with variable specificity for hairy cells. Antibody 1 was highly specific for hairy cells and was not found to react with normal or leukemic cells in this limited study. It did not react with the cells of all patients. It also did not react with all of the hairy cells of some of the positive cases. Antibodies 2 and 3 reacted with virtually all hairy cells but not with normal peripheral blood cells. However, reactions were obtained with certain leukemic myelomonoblasts and some activated B cells. The most obvious use for these three antibodies is for diagnostic purposes. They should also be helpful reagents to investigate the origin of the leukemic hairy cell. The possibility that antibody 1 detects a tumor-specific antigen is discussed.
毛细胞白血病是一种已被充分描述的临床实体，但这种白血病细胞的起源细胞及其功能仍不清楚。尽管抗酒石酸酸性磷酸酶染色已被广泛用作诊断试验，但对于这种细胞尚无完全特异性的标志物。本研究描述了三种对毛细胞具有不同特异性的单克隆鼠抗体。抗体1对毛细胞具有高度特异性，在这项有限的研究中未发现其与正常或白血病细胞发生反应。它并非与所有患者的细胞都发生反应。它也未与一些阳性病例的所有毛细胞发生反应。抗体2和3几乎与所有毛细胞发生反应，但不与正常外周血细胞发生反应。然而，某些白血病原始粒单细胞和一些活化B细胞可出现反应。这三种抗体最明显的用途是用于诊断目的。它们也应是研究白血病毛细胞起源的有用试剂。文中讨论了抗体1检测肿瘤特异性抗原的可能性。
