Miyake K, Miyake Y, Maekubo K, Asakura M, Manabe R
Am J Ophthalmol. 1983 Apr;95(4):451-6. doi: 10.1016/0002-9394(83)90264-7.
We conducted a prospective, double-masked, controlled study to determine the effects of indomethacin in preventing the development of cystoid macular edema after retinal detachment surgery. In addition to routine medication, topical indomethacin was applied to 63 eyes (52 with intact lenses and 11 aphakic) and a placebo was applied to 61 eyes (51 with intact lenses and ten aphakic) that underwent retinal detachment surgery. Indomethacin drops or placebo were instilled once an hour for five hours preoperatively and three times daily for four weeks postoperatively. Fluorescein angiography, done before surgery and four to six weeks after surgery to detect cystoid macular edema, showed that cystoid macular edema developed in 11 of 63 eyes (13%) in the indomethacin-treated group and in 20 of 61 eyes (33%) in the placebo group (P less than .01). Five of 28 eyes (18%) with cystoid macular edema in both groups and 38 of 96 eyes (40%) without cystoid macular edema in both groups had visual acuities of 20/40 or better (P less than .05).
我们进行了一项前瞻性、双盲、对照研究，以确定吲哚美辛在预防视网膜脱离手术后黄斑囊样水肿发生方面的作用。除常规用药外，对63只眼（52只晶状体完整，11只无晶状体）行视网膜脱离手术的患者应用局部吲哚美辛，对61只眼（51只晶状体完整，10只无晶状体）行视网膜脱离手术的患者应用安慰剂。术前每小时滴注一次吲哚美辛滴眼液或安慰剂，共5小时，术后每日3次，共4周。术前及术后4至6周进行荧光素血管造影以检测黄斑囊样水肿，结果显示，吲哚美辛治疗组63只眼中有11只（13%）发生黄斑囊样水肿，安慰剂组61只眼中有20只（33%）发生黄斑囊样水肿（P<0.01）。两组中有黄斑囊样水肿的28只眼中有5只（18%）以及两组中无黄斑囊样水肿的96只眼中有38只（40%）视力为20/40或更好（P<0.05）。
