Miyake K
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1977 Aug 8;203(2):81-8. doi: 10.1007/BF00413399.
Topically administered indomethacin was found to reduce the occurrence of cystoid macular edema after lens extraction. Indomethacin was given topically as 1% oil solution (sesame oil) eye drops twice or three times daily from the day before operation to the 40th day after operation. This effect suggests that prostaglandins play a leading role in the development of this disorder. It is postulated that operative irritation causes production of prostaglandins, which disrupt the blood-aqueous barrier, followed by an increase of the inflammatory mediators and debris in the aqueous. These inflammatory substances and prostaglandins themselves diffuse from the aqueous into the posterior pole of the fundus, where they induce inflammatory changes in vascular permeability in the perifoveolar capillary plexus. Clinically the cystoid macular edema then develops.
研究发现，局部应用吲哚美辛可减少晶状体摘除术后囊样黄斑水肿的发生。吲哚美辛以1%油溶液（芝麻油）滴眼液的形式局部给药，从手术前一天至术后第40天，每天滴眼两次或三次。这一作用表明前列腺素在该疾病的发生发展中起主导作用。据推测，手术刺激导致前列腺素产生，破坏血-房水屏障，随后房水中炎症介质和碎屑增加。这些炎症物质和前列腺素本身从房水扩散至眼底后极部，在那里它们引起中心凹周围毛细血管丛血管通透性的炎症改变。临床上囊样黄斑水肿随即发生。
