Schelling P, Müller S, Clauser E
Am J Physiol. 1983 Apr;244(4):R466-71. doi: 10.1152/ajpregu.1983.244.4.R466.
The origin and regulation of angiotensinogen in cerebrospinal fluid (CSF) was investigated in rats by measuring renin substrate in plasma and CSF under different experimental conditions. Nephrectomy (NX) increased the circulating and the central angiotensinogen levels. There was no correlation between the individual values of plasma and CSF. Adrenalectomy (ADX) diminished and hydrocortisone treatment augmented the angiotensinogen levels in plasma and CSF. The combination of ADX and NX caused a dissociation between peripheral and central angiotensinogen, since the values were elevated in plasma but unchanged in CSF. After the application of the converting-enzyme inhibitor captopril a significant decrease of angiotensinogen was observed in plasma only. A specific radioimmunoassay for renin substrate of rat plasma also recognized CSF angiotensinogen. There was a linear correlation between the CSF substrate levels obtained by direct and indirect measurement. In conclusion, CSF angiotensinogen appears to be immunologically similar to the plasma molecule. The angiotensinogen levels in CSF and plasma may be affected in parallel but can nevertheless be dissociated from each other.
通过在不同实验条件下测量大鼠血浆和脑脊液中的肾素底物，研究了脑脊液（CSF）中血管紧张素原的来源和调节。肾切除术（NX）增加了循环和中枢血管紧张素原水平。血浆和脑脊液的个体值之间没有相关性。肾上腺切除术（ADX）降低了血浆和脑脊液中的血管紧张素原水平，而氢化可的松治疗则增加了该水平。ADX和NX联合使用导致外周和中枢血管紧张素原之间出现解离，因为血浆中的值升高而脑脊液中的值未改变。应用转化酶抑制剂卡托普利后，仅在血浆中观察到血管紧张素原显著降低。大鼠血浆肾素底物的特异性放射免疫测定法也能识别脑脊液血管紧张素原。通过直接和间接测量获得的脑脊液底物水平之间存在线性相关性。总之，脑脊液血管紧张素原在免疫学上似乎与血浆分子相似。脑脊液和血浆中的血管紧张素原水平可能会同时受到影响，但彼此仍可能解离。
