Katovich M J, Fregly M J
Clin Exp Hypertens A. 1983;5(3):367-82. doi: 10.3109/10641968309069495.
Hypertension, induced in male rats by encapsulation of both kidneys with latex envelopes, is associated with a reduction in maximal responsiveness to beta-adrenergic stimulation. Responsiveness was assessed by measurement of both water intake and plasma renin activity following acute subcutaneous administration of graded doses of isoproterenol, a beta-adrenergic agonist. At doses of isoproterenol in excess of 6 micrograms/kg body weight, s.c., the dipsogenic response of rats with renal hypertension was significantly (p less than 0.05) less than that of normotensive controls. Basal, unstimulated plasma renin activities were similar in both the normotensive and renal hypertensive groups. However, following administration of isoproterenol at doses of 5, 10, or 20 micrograms/kg body weight, s.c., plasma renin activity was elevated significantly (p less than 0.01) in the normotensive, but only in the lowest dose in the renal hypertensive group. These results suggest that maximal responsiveness to beta-adrenergic stimulation is reduced in the renal hypertensive rat; however, the mechanism(s) responsible for the reduced beta-adrenergic responsiveness remains speculative.
通过用乳胶包膜包裹雄性大鼠的双肾所诱导的高血压，与对β-肾上腺素能刺激的最大反应性降低有关。通过在急性皮下注射分级剂量的异丙肾上腺素（一种β-肾上腺素能激动剂）后测量水摄入量和血浆肾素活性来评估反应性。当皮下注射异丙肾上腺素的剂量超过6微克/千克体重时，肾性高血压大鼠的致渴反应显著（p<0.05）低于正常血压对照组。正常血压组和肾性高血压组的基础、未刺激的血浆肾素活性相似。然而，在皮下注射5、10或20微克/千克体重剂量的异丙肾上腺素后，正常血压组的血浆肾素活性显著升高（p<0.01），而肾性高血压组仅在最低剂量时有升高。这些结果表明，肾性高血压大鼠对β-肾上腺素能刺激的最大反应性降低；然而，导致β-肾上腺素能反应性降低的机制仍属推测。
