Katovich M J, Barney C C, Fregly M J
Am J Physiol. 1981 Oct;241(4):H497-504. doi: 10.1152/ajpheart.1981.241.4.H497.
The metabolic responsiveness of spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) normotensive rats to administration of the beta-adrenergic agonist, isoproterenol, was assessed by changes in tail-skin temperature, heart rate, and plasma glucose concentration after administration of graded doses of isoproterenol. The increases in mean tail-skin temperature accompanying administration of isoproterenol at doses of 5, 10, and 40 micrograms/kg sc were significantly (P less than 0.05) greater for SH than for WKY rats. Resting colonic temperatures of the SH rats were also significantly (P less than 0.01) higher than those of the WKY normotensive rats. Mean maximal heart rates of unanesthetized SH rats after administration of isoproterenol at doses of 5, 10, and 20 micrograms/kg sc increased to levels significantly (P less than 0.05-0.01) higher than those of WKY normotensive rats. Resting heart rates were similar in both groups. Increases in plasma glucose concentration after administration of isoproterenol at doses of 5, 10, and 20 micrograms/kg sc were significantly (P less than 0.05) greater in the SH rats compared with the WKY rats. These results suggest that the SH rat has a significantly greater metabolic responsiveness to beta-adrenergic stimulation, as assessed by three separate tests of beta-adrenergic function, than does the WKY rat.
通过对自发性高血压（SH）大鼠和Wistar-Kyoto（WKY）正常血压大鼠给予不同剂量的β-肾上腺素能激动剂异丙肾上腺素后，观察其尾皮温度、心率和血浆葡萄糖浓度的变化，来评估这两种大鼠对异丙肾上腺素的代谢反应性。给予5、10和40微克/千克皮下注射剂量的异丙肾上腺素后，SH大鼠平均尾皮温度的升高显著（P<0.05）高于WKY大鼠。SH大鼠的静息结肠温度也显著（P<0.01）高于WKY正常血压大鼠。给予5、10和20微克/千克皮下注射剂量的异丙肾上腺素后，未麻醉的SH大鼠的平均最大心率增加到显著（P<0.05-0.01）高于WKY正常血压大鼠的水平。两组的静息心率相似。给予5、10和20微克/千克皮下注射剂量的异丙肾上腺素后，SH大鼠血浆葡萄糖浓度的升高显著（P<0.05）高于WKY大鼠。这些结果表明，通过三项独立的β-肾上腺素能功能测试评估，SH大鼠对β-肾上腺素能刺激的代谢反应性显著高于WKY大鼠。
