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血管扩张剂对牛冠状动脉内、外肌的作用。

Action of vasodilator agents on inner and outer muscle of bovine coronary arteries.

作者信息

Garland C J, Keatinge W R

出版信息

Eur J Pharmacol. 1983 Feb 18;87(2-3):327-30. doi: 10.1016/0014-2999(83)90347-3.

DOI:10.1016/0014-2999(83)90347-3
PMID:6341073
Abstract

Noradrenaline and adrenaline (via beta-receptors), adenosine, and prostacyclin all relaxed inner more than outer muscle in coronary arteries contracted by histamine. In submaximal concentrations, noradrenaline, and usually the other dilator hormones, produced proportionately even greater relaxation of inner than outer muscle. Inner and outer strips contracted by 5-hydroxytryptamine showed similar but smaller differences in response to noradrenaline. Outer strips contracted by methacholine were little affected by noradrenaline, though inorganic nitrite relaxed them.

摘要

去甲肾上腺素和肾上腺素(通过β受体)、腺苷和前列环素均可使组胺收缩的冠状动脉内层肌肉比外层肌肉舒张更明显。在亚最大浓度时,去甲肾上腺素以及通常其他扩张血管的激素,使内层肌肉比外层肌肉产生更大比例的舒张。5-羟色胺收缩的内层和外层肌条对去甲肾上腺素的反应显示出相似但较小的差异。乙酰甲胆碱收缩的外层肌条对去甲肾上腺素影响较小,不过无机亚硝酸盐可使其舒张。

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1
Action of vasodilator agents on inner and outer muscle of bovine coronary arteries.血管扩张剂对牛冠状动脉内、外肌的作用。
Eur J Pharmacol. 1983 Feb 18;87(2-3):327-30. doi: 10.1016/0014-2999(83)90347-3.
2
Constrictor actions of acetylcholine, 5-hydroxytryptamine and histamine on bovine coronary artery inner and outer muscle.乙酰胆碱、5-羟色胺和组胺对牛冠状动脉内、外肌的收缩作用。
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[Effect of noradrenaline and potassium ions on the electrical and contractile activity of coronary artery smooth muscle cells].[去甲肾上腺素和钾离子对冠状动脉平滑肌细胞电活动及收缩活动的影响]
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Elevation of cyclic AMP by prostacyclin is accompanied by relaxation of bovine coronary arteries and contraction of rabbit aortic rings.前列环素使环磷酸腺苷升高的同时,牛冠状动脉会舒张,而兔主动脉环会收缩。
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