Shek P N, Sabiston B H
Int J Immunopharmacol. 1983;5(1):23-33. doi: 10.1016/0192-0561(83)90068-1.
The induction of antibody formation mediated significant changes in circulating corticosterone (CS) levels in mice. On the day of the peak plaque-forming cell (PFC) response to sheep red blood cells (SRBC) or to the trinitrophenyl (TNP) hapten, the 0800 h serum CS concentration was increased. This hormonal elevation was not observed in SRBC-immunized low responder animals which did not give a significant PFC response, thus suggesting a direct correlation between immune responsiveness and hormonal changes. A change in the circadian rhythm of CS was evident in immune animals injected with SRBC. Control animals injected with saline showed a regular circadian pattern of low CS level at 0800 h followed by a high level at 1600 h. In contrast, responding animals injected with SRBC were found to have a reversed CS pattern, i.e. the hormonal concentration was high at 0800 h and low at 1600 h, on the day of the peak PFC response. This reversal of the circadian CS pattern may have important immunoregulatory significance. The immunization-induced CS response could be significantly blocked by the administration of diazepam (DZM), an effect which implies the involvement of central hypothalamic-pituitary control of the response.
抗体形成的诱导介导了小鼠循环皮质酮（CS）水平的显著变化。在对绵羊红细胞（SRBC）或三硝基苯基（TNP）半抗原产生峰值空斑形成细胞（PFC）反应的当天，08:00时血清CS浓度升高。在未产生显著PFC反应的SRBC免疫低反应动物中未观察到这种激素升高，因此表明免疫反应性与激素变化之间存在直接关联。在注射SRBC的免疫动物中，CS的昼夜节律发生了明显变化。注射生理盐水的对照动物在08:00时呈现低CS水平的规律昼夜模式，随后在16:00时升高。相比之下，在PFC反应峰值当天，注射SRBC的反应动物的CS模式相反，即激素浓度在08:00时高，在16:00时低。CS昼夜模式的这种逆转可能具有重要的免疫调节意义。给予地西泮（DZM）可显著阻断免疫诱导的CS反应，这一效应表明该反应涉及下丘脑 - 垂体中枢控制。
