Visser T J, Lamberts S W, Wilson J H, Docter R, Hennemann G
Metabolism. 1978 Apr;27(4):405-9. doi: 10.1016/0026-0495(78)90096-3.
In nine obese but otherwise healthy subjects the effect of caloric restriction on the serum concentrations of thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3), urea, uric acid, creatinine, and bilirubin was studied. Blood was obtained before and 2, 4, and 6 wk after the subjects had changed to a chemically defined diet (31 g amino acids, 44 g carbohydrate, and 1.5 g fat; 300 kcal/day). A decline of body weight to 88% and of serum T3 to 70% of the pretreatment values was observed. Creatinine and bilirubin increased to 115% and 163%, respectively. Uric acid and rT3 showed a transient rise to 148% and 180%, respectively. Serum urea was lowest (72%) from the second until the fourth week. There was a highly significant correlation between serum rT3 and uric acid (r = 0.77, p less than 0.001). The time course of the changes seems to indicate that conversion of T4 into T3 and rT3 is mediated by separate processes.
在9名肥胖但其他方面健康的受试者中，研究了热量限制对血清甲状腺素（T4）、3,3',5-三碘甲状腺原氨酸（T3）、3,3',5'-三碘甲状腺原氨酸（反T3）、尿素、尿酸、肌酐和胆红素浓度的影响。在受试者改为化学定义饮食（31克氨基酸、44克碳水化合物和1.5克脂肪；300千卡/天）之前以及之后2周、4周和6周采集血液。观察到体重下降至预处理值的88%，血清T3下降至70%。肌酐和胆红素分别升至115%和163%。尿酸和反T3分别短暂升至148%和180%。血清尿素在第二周至第四周最低（72%）。血清反T3与尿酸之间存在高度显著的相关性（r = 0.77，p < 0.001）。变化的时间过程似乎表明，T4向T3和反T3的转化是由不同过程介导的。
