肥胖低热量治疗期间膳食碳水化合物对甲状腺激素外周代谢的影响。

Effect of dietary carbohydrates during hypocaloric treatment of obesity on peripheral thyroid hormone metabolism.

作者信息

Pasquali R, Parenti M, Mattioli L, Capelli M, Cavazzini G, Baraldi G, Sorrenti G, De Benedettis G, Biso P, Melchionda N

出版信息

J Endocrinol Invest. 1982 Jan-Feb;5(1):47-52. doi: 10.1007/BF03350482.

Abstract

The effect of different hypocaloric carbohydrate (CHO) intakes was evaluated in 8 groups of obese patients in order to assess the role of the CHO and the other dietary sources in modulating the peripheral thyroid hormone metabolism. These changes were independent of those of bw. Serum T3 concentrations appear to be more easily affected than those of reverse T3 by dietary manipulation and CHO content of the diet. A fall in T3 levels during the entire period of study with respect to the basal levels occurred only when the CHO of the diet was 120 g/day or less, independent of caloric intake (360, 645 or 1200 calories). Moreover, reverse T3 concentrations were found increased during the entire period of study when total CHO were very low (40 to 50 g/day) while they demonstrated only a transient increase when CHO were at least 105 g/day (with 645 or more total calories). Indeed, our data indicate that a threshold may exist in dietary CHO, independent of caloric intake, below which modifications occur in thyroid hormone concentrations. From these results it appears that the CHO content of the diet is more important than non-CHO sources in modulating peripheral thyroid hormone metabolism and that the influence of total calories is perhaps as pronounced as that of CHO when a "permissive" amount of CHO is ingested.

摘要

为了评估碳水化合物（CHO）及其他膳食来源在调节外周甲状腺激素代谢中的作用，对8组肥胖患者进行了不同低热量碳水化合物摄入量的影响评估。这些变化与体重变化无关。血清T3浓度似乎比反T3浓度更容易受到饮食操作和饮食中CHO含量的影响。仅当饮食中的CHO为每日120克或更少时，无论热量摄入如何（360、645或1200卡路里），在整个研究期间T3水平相对于基础水平都会下降。此外，当总CHO非常低（每日40至50克）时，在整个研究期间发现反T3浓度升高，而当CHO至少为每日105克（总热量为645或更多）时，反T3浓度仅出现短暂升高。实际上，我们的数据表明，饮食中的CHO可能存在一个阈值，与热量摄入无关，低于该阈值时甲状腺激素浓度会发生变化。从这些结果看来，在调节外周甲状腺激素代谢方面，饮食中的CHO含量比非CHO来源更重要，并且当摄入“允许”量的CHO时，总热量的影响可能与CHO的影响一样显著。