Nochy D, Barres D, Camilleri J P, Bariety J, Corvol P, Menard J
Kidney Int. 1983 Feb;23(2):375-9. doi: 10.1038/ki.1983.29.
The distribution of renin was investigated by immunofluorescence in human kidney biopsy specimens (27 patients with lipoid nephrosis, 39 with Berger disease, 17 with membranous glomerulonephritis, 5 with thrombotic microangiopathy, and 7 with malignant nephroangiosclerosis). A semiquantitative assessment was carried out. Two ratios were found significatively increased in the study groups as compared with the control group: JGA + and JGA ++ which expressed, respectively, the number of fluorescent JGA in relation to the number of glomerular sections and the number of fluorescent JGA with more than six renin-containing cells (RCC) in relation to the number of immunoreactive JGA. Highest values were observed in patients with thrombotic microangiopathy and malignant nephroangiosclerosis (P less than 0.001). The above immunomorphological parameters were correlated with clinical and laboratory data. A positive dependency was found between JGA + and JGA ++ ratios and a low sodium diet, diuretic therapy and serum creatinine. A negative dependency was seen in the albumin and hemoglobin serum levels. No correlation was found with blood pressure values. These observations suggested that decreased plasma volume and impaired renal function could be factors leading to an increased renin production in the kidney.
通过免疫荧光法对人肾活检标本（27例脂性肾病患者、39例伯杰病患者、17例膜性肾小球肾炎患者、5例血栓性微血管病患者和7例恶性肾血管硬化患者）中的肾素分布进行了研究。进行了半定量评估。与对照组相比，研究组中有两个比率显著升高：JGA +和JGA ++，分别表示荧光JGA数量与肾小球切片数量的比值以及含有超过6个含肾素细胞（RCC）的荧光JGA数量与免疫反应性JGA数量的比值。在血栓性微血管病和恶性肾血管硬化患者中观察到最高值（P小于0.001）。上述免疫形态学参数与临床和实验室数据相关。发现JGA +和JGA ++比率与低钠饮食、利尿剂治疗和血清肌酐之间存在正相关。在血清白蛋白和血红蛋白水平方面观察到负相关。未发现与血压值相关。这些观察结果表明，血浆容量减少和肾功能受损可能是导致肾脏肾素产生增加的因素。
